OperaV1, Main, Exploration, bibRecord, 000768

SIRT1 and the clock gene machinery in colorectal cancer.

Identifieur interne : 000768 ( Main/Exploration ); précédent : 000767; suivant : 000769

SIRT1 and the clock gene machinery in colorectal cancer.

Auteurs : Valerio Pazienza [Italie] ; Ada Piepoli ; Anna Panza ; Maria Rosa Valvano ; Giorgia Benegiamo ; Manlio Vinciguerra ; Angelo Andriulli ; Gianluigi Mazzoccoli

Source :

Cancer investigation ; 2012.

RBID : pubmed:22149272

English descriptors

KwdEn :
- Aged, Aged, 80 and over, CLOCK Proteins (biosynthesis), CLOCK Proteins (genetics), Caco-2 Cells, Cell Line, Tumor, Cell Transformation, Neoplastic (genetics), Cell Transformation, Neoplastic (metabolism), Colorectal Neoplasms (genetics), Colorectal Neoplasms (metabolism), Female, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Sirtuin 1 (biosynthesis), Sirtuin 1 (genetics), Transfection.
MESH :
- chemical , biosynthesis : CLOCK Proteins, Sirtuin 1.
- chemical , genetics : CLOCK Proteins, Sirtuin 1.
- genetics : Cell Transformation, Neoplastic, Colorectal Neoplasms.
- metabolism : Cell Transformation, Neoplastic, Colorectal Neoplasms.
- Aged, Aged, 80 and over, Caco-2 Cells, Cell Line, Tumor, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Transfection.

Abstract

SIRT1 and the clock genes are involved in carcinogenesis. We evaluated SIRT1 expression in 19 human colorectal cancer (CRC) specimens and clock gene expression in SIRT1-overexpressing CaCo2 and SW480 cells. In CRC, SIRT1 mean expression level was decreased. Compared to CaCo2 cells, SW480 cells displayed lower levels of SIRT1 and PER3 and higher levels of ARNTL1, CLOCK, PER1, PER2, CRY1, TIPIN, and CSNKIE. SIRT1 overexpression induced PER1 upregulation in CaCo2 and downregulation in SW480 cells. SIRT1 expression was heterogeneous in human CRC and in CRC cell lines. These results might have relevant implications for a better understanding of colorectal carcinogenesis.

DOI: 10.3109/07357907.2011.640650
PubMed: 22149272

Affiliations:

Italie

Le document en format XML

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<wicri:regionArea>Division and Laboratory of Gastroenterology, IRCCS Casa Sollievo della Sofferenza, Research Hospital, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG)</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">SIRT1 and the clock gene machinery in colorectal cancer.</title>
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<author><name sortKey="Panza, Anna" sort="Panza, Anna" uniqKey="Panza A" first="Anna" last="Panza">Anna Panza</name>
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<author><name sortKey="Valvano, Maria Rosa" sort="Valvano, Maria Rosa" uniqKey="Valvano M" first="Maria Rosa" last="Valvano">Maria Rosa Valvano</name>
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<author><name sortKey="Benegiamo, Giorgia" sort="Benegiamo, Giorgia" uniqKey="Benegiamo G" first="Giorgia" last="Benegiamo">Giorgia Benegiamo</name>
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<author><name sortKey="Vinciguerra, Manlio" sort="Vinciguerra, Manlio" uniqKey="Vinciguerra M" first="Manlio" last="Vinciguerra">Manlio Vinciguerra</name>
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<author><name sortKey="Andriulli, Angelo" sort="Andriulli, Angelo" uniqKey="Andriulli A" first="Angelo" last="Andriulli">Angelo Andriulli</name>
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<author><name sortKey="Mazzoccoli, Gianluigi" sort="Mazzoccoli, Gianluigi" uniqKey="Mazzoccoli G" first="Gianluigi" last="Mazzoccoli">Gianluigi Mazzoccoli</name>
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<series><title level="j">Cancer investigation</title>
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<term>Cell Transformation, Neoplastic (genetics)</term>
<term>Cell Transformation, Neoplastic (metabolism)</term>
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<term>Colorectal Neoplasms</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Colorectal Neoplasms</term>
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<term>Aged, 80 and over</term>
<term>Caco-2 Cells</term>
<term>Cell Line, Tumor</term>
<term>Female</term>
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<front><div type="abstract" xml:lang="en">SIRT1 and the clock genes are involved in carcinogenesis. We evaluated SIRT1 expression in 19 human colorectal cancer (CRC) specimens and clock gene expression in SIRT1-overexpressing CaCo2 and SW480 cells. In CRC, SIRT1 mean expression level was decreased. Compared to CaCo2 cells, SW480 cells displayed lower levels of SIRT1 and PER3 and higher levels of ARNTL1, CLOCK, PER1, PER2, CRY1, TIPIN, and CSNKIE. SIRT1 overexpression induced PER1 upregulation in CaCo2 and downregulation in SW480 cells. SIRT1 expression was heterogeneous in human CRC and in CRC cell lines. These results might have relevant implications for a better understanding of colorectal carcinogenesis.</div>
</front>
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<name sortKey="Piepoli, Ada" sort="Piepoli, Ada" uniqKey="Piepoli A" first="Ada" last="Piepoli">Ada Piepoli</name>
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SIRT1 and the clock gene machinery in colorectal cancer.

SIRT1 and the clock gene machinery in colorectal cancer.

Source :

English descriptors

Abstract

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